Endocrine Abstracts

A 52-year-old female patient with no previous history of interest, and with no prescribed habitual chronic treatment, was admitted to our hospital to be studied for symptomatic hypoglycemias of one month of evolution. Symptoms consisted of malaise, hunger, tremors and profuse sweating that disappeared with food ingestion. She referred hypoglycemic (up to 40 mg/dl) episodes daily, both in fasting and postprandial periods. She even suffered nocturnal episodes that woke her up. O...

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Since November 2020 the use of this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and December 2021 in patients with DM3c in which FGM implementat...

Objective: Flash glucose monitoring (FGM) facilitates non-invasive glucose level assessment. Since November 2020 this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and January 2023 in patients with DM3c.Results:...

Next Generation Sequencing (NGS) is becoming widely used for genetic diagnosis. While its capacity for detection of human genetic variations (GV) is outstanding, drawbacks is the identification of numerous GV of which functional significance cannot be predicted in silico by computer programs (variants of uncertain significance, VUS). Currently, only sensitive (but also expensive and time-demanding) in vitro cell assays, can trustfully ascertain pathogenicity ...

It is known that the synthesis and release of pituitary GH is controlled by complex neuroendocrine mechanisms that involve several neuropeptides, such as GHRH, SST, PACAP, TRH, GnRH, Ghrelin, among other regulators. Previous reports indicate that, during vertebrate evolution, the potency and efficacy of these secretagogues may vary and play differential effects upon GH regulation. In this work we aimed to study, in vitro, the capacity of these peptides to control the ...